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The mitochondrial cysteinyl-tRNA synthase (CARS2) has been identified as the main cellular source of CysSSH, yielding free CysSSH and co-translationally inserting persulphidated cysteine into nascent polypeptides
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Another recent example of a class I c-MET inhibitor in earlier phases of clinical development is AMG - 337 (Amgen, Thousand Oaks, California, USA), an orally bioavailable highly selective inhibitor of the c-MET receptor with a half maximal inhibitory concentration (IC50) of 1 nM which has reached phase II studies in patients with GI cancer or other MET-amplified solid tumors [112]
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