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Eli Lilly is offering expanded access to retatrutide, its investigational triple hormone receptor agonist that demonstrated substantial weight loss in phase 3 studies, and not all clinicians are happy about the move. “
doi: 10.3389/fimmu.2026.1769281 Received 16 December 2025 Revised 08 April 2026 Accepted 13 April 2026 Published 29 April 2026 Volume 17 - 2026 Edited by Douglas Sborov, The University of Utah, United States Reviewed by Noémie Leblay, University of Calgary, Canada Xuan Jiang, Shanghai Jiao Tong University, China Updates Copyright © 2026 Horenstein, Frerichs, Faini, van de Donk and Malavasi
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While mouse studies do not directly translate to humans, the concentration of beta-3 receptors in human visceral fat tissue suggests a similar preferential targeting is plausible